Literature summary for 5.3.3.2 extracted from

Thompson, K.; Dunford, J.E.; Ebetino, F.H.; Rogers, M.J.
Identification of a bisphosphonate that inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase (2002), Biochem. Biophys. Res. Commun., 290, 869-873.

Inhibitors

Inhibitors	Comment	Organism	Structure
4-aminophenyl-2-ethane-1,1-bisphosphonic acid	weak. Due to inhibition of more than one enzyme in the mevalonate pathway may lead to an increase in antiresorptive potency compared to bisphosphonates that only inhibit farnesyl diphosphate synthase	Homo sapiens

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

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Release 2023.1 (January 2023)