Literature summary for 5.3.3.18 extracted from

Ismail, W.; El-Said Mohamed, M.; Wanner, B.; Datsenko, K.; Eisenreich, W.; Rohdich, F.; Bacher, A.; Fuchs, G.
Functional genomics by NMR spectroscopy: Phenylacetate catabolism in Escherichia coli (2003), Eur. J. Biochem., 270, 3047-3054.

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Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P77467	-	-

Synonyms

Synonyms	Comment	Organism
paaG	-	Escherichia coli

General Information

General Information	Comment	Organism
physiological function	mutants with a deletion of paaG gene are unable to grow on phenylacetate as carbon source. Incubation of a paaG mutant with [U-13C8]phenylacetate yields ring-1,2-dihydroxy-1,2-dihydrophenylacetyl lactone. The paaG mutant also converts phenylacetate into ortho-hydroxyphenylacetate, a dead end product of phenylacetate catabolism. The catabolic pathway of phenylacetate involves CoA thioesters. Phenylacetyl-CoA is attacked by a ring-oxygenase/reductase, PaaABCDE proteins, generating a hydroxylated and reduced derivative of phenylacetyl-CoA. The intermediate CoA ester is further metabolized in a complex reaction sequence comprising enoyl-CoA isomerization/hydration, nonoxygenolytic ring opening, and dehydrogenation catalyzed by the PaaG and PaaZ proteins	Escherichia coli

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Release 2023.1 (January 2023)