Literature summary for 5.3.3.1 extracted from

Penning, T.M.; Covey, D.F.; Talalay, P.
Inactivation of DELTA5-3-oxo steroid isomerase with active-site-directed acetylenic steroids (1981), Biochem. J., 193, 217-227.

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Inhibitors

Inhibitors	Comment	Organism	Structure
10beta-(1-Oxoprop-2-ynyl)oestr-4-ene-3,17-dione	irreversible, time-dependent, active-site directed	Comamonas testosteroni
17beta-(1-Oxoprop-2-ynyl)androst-4-en-3-one	irreversible, time-dependent, active-site directed	Comamonas testosteroni
17beta-Hydroxy-5,10-seco-oestr-4-yne-3,10-dione	irreversible, time-dependent, active-site directed	Comamonas testosteroni
5,10-Seco-oestr-4-yne-3,10,17-trione	irreversible, time-dependent, active-site directed	Comamonas testosteroni
additional information	overview: inactivation by active-site directed acetylenic steroids	Comamonas testosteroni

Organism

Organism	UniProt	Comment	Textmining
Comamonas testosteroni	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5-Androstene-3,17-dione	-	Comamonas testosteroni	4-Androstene-3,17-dione	-	?
5-Pregnene-3,20-dione	-	Comamonas testosteroni	4-Pregnene-3,20-dione	-	?

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Release 2023.1 (January 2023)