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Literature summary for 5.3.2.1 extracted from

  • Molnar, V.; Garai, J.
    Plant-derived anti-inflammatory compounds affect MIF tautomerase activity (2005), Int. Immunopharmacol., 5, 849-856.
    View publication on PubMed
Search for more literature for 5.3.2.1

Inhibitors

Inhibitors Comment Organism Structure
acetaminophen IC50 ketonase reaction 1.0 microM, pH 6.5, room temperatur, IC50 enolase reaction 2.6 microM, pH 6.2, room temperatur Bos taurus
boldine IC50 ketonase reaction 5.7 microM, pH 6.5, room temperatur, IC50 enolase reaction 77.9 microM, pH 6.2, room temperatur Bos taurus
caffeic acid IC50 ketonase reaction 0.5 microM, pH 6.5, room temperatur, IC50 enolase reaction 2.0 microM, pH 6.2, room temperatur Bos taurus
carnosic acid IC50 ketonase reaction 15.5 microM, pH 6.5, room temperatur, IC50 enolase reaction 115.8 microM, pH 6.2, room temperatur Bos taurus
chlorogenic acid IC50 ketonase reaction 7.6 microM, pH 6.5, room temperatur, IC50 enolase reaction 127.0 microM, pH 6.2, room temperatur Bos taurus
Cinnamic acid IC50 ketonase reaction 20.9 microM, pH 6.5, room temperatur, IC50 enolase reaction 229.6 microM, pH 6.2, room temperatur Bos taurus
coumarin IC50 ketonase reaction 88.8 microM, pH 6.5, room temperatur Bos taurus
curcumin IC50 ketonase reaction 0.7 microM, pH 6.5, room temperatur, IC50 enolase reaction 12.2 microM, pH 6.2, room temperatur Bos taurus
eugenol IC50 ketonase reaction 165.9 microM, pH 6.5, room temperatur Bos taurus
ferulic acid IC50 ketonase reaction 31.7 microM, pH 6.5, room temperatur, IC50 enolase reaction 85.3 microM, pH 6.2, room temperatur Bos taurus
folic acid IC50 ketonase reaction 62.7 microM, pH 6.5, room temperatur, IC50 enolase reaction 80.2 microM, pH 6.2, room temperatur Bos taurus
galangin IC50 ketonase reaction 36.9 microM, pH 6.5, room temperatur, IC50 enolase reaction 143.7 microM, pH 6.2, room temperatur Bos taurus
Ibuprofen IC50 ketonase reaction 10334.3, pH 6.5, room temperatur, IC50 enolase reaction 109.6 microM, pH 6.2, room temperatur Bos taurus
isoeugenol IC50 ketonase reaction 50.4 microM, pH 6.5, room temperatur, IC50 enolase reaction 129.0 microM, pH 6.2, room temperatur Bos taurus
methotrexate IC50 ketonase reaction 15.6 microM, pH 6.5, room temperatur, IC50 enolase reaction 63.7 microM, pH 6.2, room temperatur Bos taurus
additional information 50% inhibition could not be attained: estragol, gentisic acid, tropolone Bos taurus
o-coumaric acid IC50 ketonase reaction 87.8 microM, pH 6.5, room temperatur, IC50 enolase reaction 175.7 microM, pH 6.2, room temperatur Bos taurus
p-coumaric acid IC50 ketonase reaction 18.1 microM, pH 6.5, room temperatur, IC50 enolase reaction 103.3 microM, pH 6.2, room temperatur Bos taurus
parthenolide IC50 ketonase reaction 3624.1 microM, pH 6.5, room temperatur Bos taurus
Phenylbutazone IC50 ketonase reaction 7126.7 microM, pH 6.5, room temperatur, IC50 enolase reaction 376.6 microM, pH 6.2, room temperatur Bos taurus
phloretin IC50 ketonase reaction 4.8 microM, pH 6.5, room temperatur, IC50 enolase reaction 84.1 microM, pH 6.2, room temperatur Bos taurus
piroxicam IC50 ketonase reaction 120.9 microM, pH 6.5, room temperatur, IC50 enolase reaction 74.8 microM, pH 6.2, room temperatur Bos taurus
Quinine IC50 ketonase reaction 34.9 microM, pH 6.5, room temperatur, IC50 enolase reaction 156.3 microM, pH 6.2, room temperatur Bos taurus
resveratrol IC50 ketonase reaction 1.9 microM, pH 6.5, room temperatur, IC50 enolase reaction 28.0 microM, pH 6.2, room temperatur Bos taurus
rosmarinic acid IC50 ketonase reaction 13.8 microM, pH 6.5, room temperatur, IC50 enolase reaction 65.6 microM, pH 6.2, room temperatur Bos taurus
scopoletin IC50 ketonase reaction 133.8 microM, pH 6.5, room temperatur Bos taurus
umbelliferone IC50 ketonase reaction 2.6 microM, pH 6.5, room temperatur, IC50 enolase reaction 19.5 microM, pH 6.2, room temperatur Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
keto-phenylpyruvate
-
 Bos taurus enol-phenylpyruvate
-
 r

Synonyms

Synonyms Comment Organism
Macrophage migration inhibitory factor
-
 Bos taurus
MIF
-
 Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0005 0.002 IC50 ketonase reaction 0.5 microM, pH 6.5, room temperatur, IC50 enolase reaction 2.0 microM, pH 6.2, room temperatur Bos taurus caffeic acid
0.0007
-
 IC50 ketonase reaction 0.7 microM, pH 6.5, room temperatur Bos taurus curcumin
0.001
-
 IC50 ketonase reaction 1.0 microM, pH 6.5, room temperatur Bos taurus acetaminophen
0.0019
-
 IC50 ketonase reaction 1.9 microM, pH 6.5, room temperatur Bos taurus resveratrol
0.0026
-
 IC50 enolase reaction 2.6 microM, pH 6.2, room temperatur Bos taurus acetaminophen
0.0026 0.0195 IC50 ketonase reaction 2.6 microM, pH 6.5, room temperatur, IC50 enolase reaction 19.5 microM, pH 6.2, room temperatur Bos taurus umbelliferone
0.0048
-
 IC50 ketonase reaction 4.8 microM, pH 6.5, room temperatur Bos taurus phloretin
0.0057
-
 IC50 ketonase reaction 5.7 microM, pH 6.5, room temperatur Bos taurus boldine
0.0076
-
 IC50 ketonase reaction 7.6 microM, pH 6.5, room temperatur Bos taurus chlorogenic acid
0.0122
-
 IC50 enolase reaction 12.2 microM, pH 6.2, room temperatur Bos taurus curcumin
0.0138
-
 IC50 ketonase reaction 13.8 microM, pH 6.5, room temperatur Bos taurus rosmarinic acid
0.0155
-
 IC50 ketonase reaction 15.5 microM, pH 6.5, room temperatur Bos taurus carnosic acid
0.0156
-
 IC50 ketonase reaction 15.6 microM, pH 6.5, room temperatur Bos taurus methotrexate
0.0181 0.1033 IC50 ketonase reaction 18.1 microM, pH 6.5, room temperatur, IC50 enolase reaction 103.3 microM, pH 6.2, room temperatur Bos taurus p-coumaric acid
0.0209 0.2296 IC50 ketonase reaction 20.9 microM, pH 6.5, room temperatur, IC50 enolase reaction 229.6 microM, pH 6.2, room temperatur Bos taurus Cinnamic acid
0.028
-
 IC50 enolase reaction 28.0 microM, pH 6.2, room temperatur Bos taurus resveratrol
0.0317
-
 IC50 ketonase reaction 31.7 microM, pH 6.5, room temperatur Bos taurus ferulic acid
0.0349
-
 IC50 ketonase reaction 34.9 microM, pH 6.5, room temperatur Bos taurus Quinine
0.0369
-
 IC50 ketonase reaction 36.9 microM, pH 6.5, room temperatur Bos taurus galangin
0.0504
-
 IC50 ketonase reaction 50.4 microM, pH 6.5, room temperatur Bos taurus isoeugenol
0.0627
-
 IC50 ketonase reaction 62.7 microM, pH 6.5, room temperatur Bos taurus folic acid
0.0637
-
 IC50 enolase reaction 63.7 microM, pH 6.2, room temperatur Bos taurus methotrexate
0.0656
-
 IC50 enolase reaction 65.6 microM, pH 6.2, room temperatur Bos taurus rosmarinic acid
0.0748
-
 IC50 enolase reaction 74.8 microM, pH 6.2, room temperatur Bos taurus piroxicam
0.0779
-
 IC50 enolase reaction 77.9 microM, pH 6.2, room temperatur Bos taurus boldine
0.0802
-
 IC50 enolase reaction 80.2 microM, pH 6.2, room temperatur Bos taurus folic acid
0.0802
-
 80.2 microM Bos taurus folic acid
0.0841
-
 IC50 enolase reaction 84.1 microM, pH 6.2, room temperatur Bos taurus phloretin
0.0853
-
 IC50 enolase reaction 85.3 microM, pH 6.2, room temperatur Bos taurus ferulic acid
0.0878
-
 IC50 ketonase reaction 87.8 microM, pH 6.5, room temperatur Bos taurus o-coumaric acid
0.0888
-
 IC50 ketonase reaction 88.8 microM, pH 6.5, room temperatur Bos taurus coumarin
0.1096
-
 IC50 enolase reaction 109.6 microM, pH 6.2, room temperatur Bos taurus Ibuprofen
0.1158
-
 IC50 enolase reaction 115.8 microM, pH 6.2, room temperatur Bos taurus carnosic acid
0.1209
-
 IC50 ketonase reaction 120.9 microM, pH 6.5, room temperatur Bos taurus piroxicam
0.127
-
 IC50 enolase reaction 127.0 microM, pH 6.2, room temperatur Bos taurus chlorogenic acid
0.129
-
 IC50 enolase reaction 129.0 microM, pH 6.2, room temperatur Bos taurus isoeugenol
0.1338
-
 IC50 ketonase reaction 133.8 microM, pH 6.5, room temperatur Bos taurus scopoletin
0.1437
-
 IC50 enolase reaction 143.7 microM, pH 6.2, room temperatur Bos taurus galangin
0.1563
-
 IC50 enolase reaction 156.3 microM, pH 6.2, room temperatur Bos taurus Quinine
0.1659
-
 IC50 ketonase reaction 165.9 microM, pH 6.5, room temperatur Bos taurus eugenol
0.1757
-
 IC50 enolase reaction 175.7 microM, pH 6.2, room temperatur Bos taurus o-coumaric acid
0.3766
-
 IC50 enolase reaction 376.6 microM, pH 6.2, room temperatur Bos taurus Phenylbutazone
3.6241
-
 IC50 ketonase reaction 3624.1 microM, pH 6.5, room temperatur Bos taurus parthenolide
7.1267
-
 IC50 ketonase reaction 7126.7 microM, pH 6.5, room temperatur Bos taurus Phenylbutazone
10.3343
-
 IC50 ketonase reaction 10334.3 microM, pH 6.5, room temperatur Bos taurus Ibuprofen