Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.3.1.9 extracted from

  • Desvergnes, S.; Courtiol-Legourd, S.; Daher, R.; Dabrowski, M.; Salmon, L.; Therisod, M.
    Synthesis and evaluation of malonate-based inhibitors of phosphosugar-metabolizing enzymes: class II fructose-1,6-bis-phosphate aldolases, type I phosphomannose isomerase, and phosphoglucose isomerase (2012), Bioorg. Med. Chem., 20, 1511-1520.
    View publication on PubMed
Search for more literature for 5.3.1.9

Inhibitors

Inhibitors Comment Organism Structure
5-deoxy-5-malonate-D-arabinonohydroxamic acid
-
 Saccharomyces cerevisiae
5-phospho-D-arabinonohydroxamic acid
-
 Saccharomyces cerevisiae
N,2,3,4,5-pentahydroxypentanamide
-
 Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.084
-
 D-glucose 6-phosphate in 50 mM HEPES buffer, pH 7.1, at 25°C Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucose 6-phosphate Saccharomyces cerevisiae
-
 D-fructose 6-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 6-phosphate
-
 Saccharomyces cerevisiae D-fructose 6-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PGI
-
 Saccharomyces cerevisiae
Phosphoglucose isomerase
-
 Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00023
-
 5-phospho-D-arabinonohydroxamic acid in 50 mM HEPES buffer, pH 7.1, at 25°C Saccharomyces cerevisiae
5.54
-
 N,2,3,4,5-pentahydroxypentanamide in 50 mM HEPES buffer, pH 7.1, at 25°C Saccharomyces cerevisiae

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.29
-
 in 50 mM HEPES buffer, pH 7.1, at 25°C Saccharomyces cerevisiae 5-deoxy-5-malonate-D-arabinonohydroxamic acid