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Literature summary for 5.3.1.9 extracted from

  • Wu, R.; Xie, H.; Cao, Z.; Mo, Y.
    Combined quantum mechanics/molecular mechanics study on the reversible isomerization of glucose and fructose catalyzed by Pyrococcus furiosus phosphoglucose isomerase (2008), J. Am. Chem. Soc., 130, 7022-7031.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
Zn2+ the coordination shell of Zn2+ changes significantly from the initial static crystal conformation to the equilibrated state of the enzyme-D-fructose 6-phosphate complex. Although Zn2+ is not directly involved in the reaction, the metal ion as a structural anchor constructs a hydrogen bond wire to connect the substrate to the outer region, providing a potential channel for hydrogen exchange between the substrate and solvent Pyrococcus furiosus

Organism

Organism UniProt Comment Textmining
Pyrococcus furiosus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
alpha-D-glucose 6-phosphate = beta-D-fructofuranose 6-phosphate on the basis of the calculations and simulations, a zwitterionic intermediate mechanism for the low-energy enzymatic reaction is proposed, involving both proton and hydride transfers Pyrococcus furiosus
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 6-phosphate
-
 Pyrococcus furiosus D-fructose 6-phosphate
-
 r