Literature summary for 5.3.1.9 extracted from

Berrisford, J.M.; Akerboom, J.; Brouns, S.; Sedelnikova, S.E.; Turnbull, A.P.; van der Oost, J.; Salmon, L.; Hardre, R.; Murray, I.A.; Blackburn, G.M.; Rice, D.W.; Baker, P.J.
The structures of inhibitor complexes of Pyrococcus furiosus phosphoglucose isomerase provide insights into substrate binding and catalysis (2004), J. Mol. Biol., 343, 649-657.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
native form and in comlex with 5-phospho-D-arabinonate, in presence and absence of Mn2+	Pyrococcus furiosus

Inhibitors

Inhibitors	Comment	Organism	Structure
5-phospho-D-arabinonate	-	Pyrococcus furiosus
EDTA	complete inhibition	Pyrococcus furiosus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mn2+	-	Pyrococcus furiosus

Organism

Organism	UniProt	Comment	Textmining
Pyrococcus furiosus	P83194	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
alpha-D-glucose 6-phosphate = beta-D-fructofuranose 6-phosphate	mechanism is based on an enediol intermediate	Pyrococcus furiosus	a

Renatured (Commentary)

Renatured (Comment)	Organism
activity of EDTA-inhibited enzyme is completely restored by addition of manganese	Pyrococcus furiosus

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
7.7	-	50°C, pH 7.0	Pyrococcus furiosus
12	-	70°C, pH 7.0	Pyrococcus furiosus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-fructose 6-phosphate	-	Pyrococcus furiosus	D-glucose 6-phosphate	-	r
D-glucose 6-phosphate	-	Pyrococcus furiosus	D-fructose 6-phosphate	-	r

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Release 2023.1 (January 2023)