Cloned (Comment) | Organism |
---|---|
- |
Pyrococcus horikoshii |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EDTA | 0.1 mM, about 50% inhibition | Pyrococcus horikoshii |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0986 | - |
beta-D-mannose 6-phosphate | pH 7.6, 65°C | Pyrococcus horikoshii |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | 2 mM, maximum activity | Pyrococcus horikoshii | |
Co2+ | 2 mM, about 80% of the activity with Cu2+ | Pyrococcus horikoshii | |
Mn2+ | 2 mM, about 55% of the activity with Cu2+ | Pyrococcus horikoshii | |
additional information | absolute requirement for divalent cation | Pyrococcus horikoshii |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
52900 | - |
x * 52900, SDS-PAGE | Pyrococcus horikoshii |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pyrococcus horikoshii | O58649 | bifunctional enzyme with mannose-6-phosphate isomerase and sugar-1-phosphate nucleotidylyltransferase activities, EC 5.3.1.8 and EC 2.7.7.13, respectively | - |
Pyrococcus horikoshii DSM 12428 | O58649 | bifunctional enzyme with mannose-6-phosphate isomerase and sugar-1-phosphate nucleotidylyltransferase activities, EC 5.3.1.8 and EC 2.7.7.13, respectively | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-D-mannose 6-phosphate | - |
Pyrococcus horikoshii | beta-D-fructose 6-phosphate | - |
? | |
beta-D-mannose 6-phosphate | - |
Pyrococcus horikoshii DSM 12428 | beta-D-fructose 6-phosphate | - |
? | |
beta-D-mannose 6-phosphate | - |
Pyrococcus horikoshii ATCC 700860 | beta-D-fructose 6-phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 52900, SDS-PAGE | Pyrococcus horikoshii |
More | mannose-6-phosphate isomerase activity is abolished by deletion of the C-terminal 14 residues. The N-terminal region plays an important role in the solubility of the entire protein and in the acquisition of the correct structure | Pyrococcus horikoshii |
Synonyms | Comment | Organism |
---|---|---|
PH0925 | - |
Pyrococcus horikoshii |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
95 | - |
- |
Pyrococcus horikoshii |