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Literature summary for 5.3.1.8 extracted from

  • Desvergnes, S.; Courtiol-Legourd, S.; Daher, R.; Dabrowski, M.; Salmon, L.; Therisod, M.
    Synthesis and evaluation of malonate-based inhibitors of phosphosugar-metabolizing enzymes: class II fructose-1,6-bis-phosphate aldolases, type I phosphomannose isomerase, and phosphoglucose isomerase (2012), Bioorg. Med. Chem., 20, 1511-1520.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5-deoxy-5-malonyl-D-arabinonohydroxamic acid
-
Escherichia coli
5-phospho-D-arabinonohydroxamic acid
-
Escherichia coli
N,2,3,4,5-pentahydroxypentanamide
-
Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.354
-
D-mannose 6-phosphate in 50 mM HEPES buffer, pH 7.1, at 25°C Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-Mannose 6-phosphate Escherichia coli
-
D-Fructose 6-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Mannose 6-phosphate
-
Escherichia coli D-Fructose 6-phosphate
-
?

Synonyms

Synonyms Comment Organism
Phosphomannose isomerase
-
Escherichia coli
PMI
-
Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0008
-
5-phospho-D-arabinonohydroxamic acid in 50 mM HEPES buffer, pH 7.1, at 25°C Escherichia coli
0.162
-
5-deoxy-5-malonyl-D-arabinonohydroxamic acid in 50 mM HEPES buffer, pH 7.1, at 25°C Escherichia coli
10
-
N,2,3,4,5-pentahydroxypentanamide in 50 mM HEPES buffer, pH 7.1, at 25°C Escherichia coli