Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a DELTApmi1 enzyme knockout mutant cell, that shows a significantly reduced growth rate at a high concentration of Man. Both inadequate and replete Man leads to an accumulation of intracellular Man-6-P and a reduction in the amount of alpha-glucan in the cell wall. Uncoupling of the link between energy production and glycosylation by deletion of the pmi1 gene leads to phenotypes such as defects in cell wall integrity, abnormal morphology and reduced conidiation, overview | Aspergillus fumigatus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | - |
Aspergillus fumigatus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-Mannose 6-phosphate | Aspergillus fumigatus | - |
D-Fructose 6-phosphate | - |
r | |
D-Mannose 6-phosphate | Aspergillus fumigatus YJ-407 | - |
D-Fructose 6-phosphate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aspergillus fumigatus | Q66WM4 | gene pmi1 | - |
Aspergillus fumigatus YJ-407 | Q66WM4 | gene pmi1 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-Mannose 6-phosphate | - |
Aspergillus fumigatus | D-Fructose 6-phosphate | - |
r | |
D-Mannose 6-phosphate | - |
Aspergillus fumigatus YJ-407 | D-Fructose 6-phosphate | - |
r |
Synonyms | Comment | Organism |
---|---|---|
Phosphomannose isomerase | - |
Aspergillus fumigatus |
Pmi1 | - |
Aspergillus fumigatus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Aspergillus fumigatus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
assay at | Aspergillus fumigatus |
General Information | Comment | Organism |
---|---|---|
malfunction | uncoupling of the link between energy production and glycosylation by deletion of the pmi1 gene leads to phenotypes such as defects in cell wall integrity, abnormal morphology and reduced conidiation, overview | Aspergillus fumigatus |
metabolism | the enzyme catalyzes the first committed step in the synthesis of mannose-containing sugar chains and provides a link between glucose metabolism and mannosylation | Aspergillus fumigatus |