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Literature summary for 5.3.1.8 extracted from

  • Fang, W.; Yu, X.; Wang, B.; Zhou, H.; Ouyang, H.; Ming, J.; Jin, C.
    Characterization of the Aspergillus fumigatus phosphomannose isomerase Pmi1 and its impact on cell wall synthesis and morphogenesis (2009), Microbiology, 155, 3281-3293.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information construction of a DELTApmi1 enzyme knockout mutant cell, that shows a significantly reduced growth rate at a high concentration of Man. Both inadequate and replete Man leads to an accumulation of intracellular Man-6-P and a reduction in the amount of alpha-glucan in the cell wall. Uncoupling of the link between energy production and glycosylation by deletion of the pmi1 gene leads to phenotypes such as defects in cell wall integrity, abnormal morphology and reduced conidiation, overview Aspergillus fumigatus

Localization

Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
Aspergillus fumigatus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-Mannose 6-phosphate Aspergillus fumigatus
-
D-Fructose 6-phosphate
-
r
D-Mannose 6-phosphate Aspergillus fumigatus YJ-407
-
D-Fructose 6-phosphate
-
r

Organism

Organism UniProt Comment Textmining
Aspergillus fumigatus Q66WM4 gene pmi1
-
Aspergillus fumigatus YJ-407 Q66WM4 gene pmi1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Mannose 6-phosphate
-
Aspergillus fumigatus D-Fructose 6-phosphate
-
r
D-Mannose 6-phosphate
-
Aspergillus fumigatus YJ-407 D-Fructose 6-phosphate
-
r

Synonyms

Synonyms Comment Organism
Phosphomannose isomerase
-
Aspergillus fumigatus
Pmi1
-
Aspergillus fumigatus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Aspergillus fumigatus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
assay at Aspergillus fumigatus

General Information

General Information Comment Organism
malfunction uncoupling of the link between energy production and glycosylation by deletion of the pmi1 gene leads to phenotypes such as defects in cell wall integrity, abnormal morphology and reduced conidiation, overview Aspergillus fumigatus
metabolism the enzyme catalyzes the first committed step in the synthesis of mannose-containing sugar chains and provides a link between glucose metabolism and mannosylation Aspergillus fumigatus