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Literature summary for 5.3.1.6 extracted from

  • Faria, J.; Loureiro, I.; Santarem, N.; Cecilio, P.; Macedo-Ribeiro, S.; Tavares, J.; Cordeiro-da-Silva, A.
    Disclosing the essentiality of ribose-5-phosphate isomerase B in trypanosomatids (2016), Sci. Rep., 6, 26937 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Leishmania infantum A4I3S4
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-

Synonyms

Synonyms Comment Organism
LINJ_28_2100
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 Leishmania infantum
RpiB
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 Leishmania infantum

General Information

General Information Comment Organism
physiological function gene is essential for parasite survival. Mutant promastigotes complemented with an episomal copy of RpiB carrying a mutation that abolishes isomerase activity exhibit no defect in growth, metacyclogenesis or macrophage infection. An impairment in intracellular amastigotes' replication is observed in these mutants, and mice infected withthe mutants have a reduced parasite burden in the liver Leishmania infantum