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Literature summary for 5.3.1.5 extracted from
- Comparative kinetics of D-xylose and D-glucose isomerase activities of the D-xylose isomerase from Thermus aquaticus HB8 (1990), Biol. Chem. Hoppe-Seyler, 371, 527-536.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-O-Methyl-D-xylose | - |
Thermus aquaticus |  |
| Ca2+ | weak inhibition | Thermus aquaticus | |
| Cu2+ | strong inhibition | Thermus aquaticus | |
| D-Lyxose | - |
Thermus aquaticus | |
| D-xylitol | - |
Thermus aquaticus | |
| Fe2+ | weak inhibition | Thermus aquaticus | |
| Hg2+ | no influence on activity | Thermus aquaticus | |
| Ni2+ | weak inhibition | Thermus aquaticus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 8 | - |
D-xylulose | - |
Thermus aquaticus | |
| 15 | - |
D-xylose | - |
Thermus aquaticus | |
| 93 | - |
D-xylose | D-glucose | Thermus aquaticus | |
| 145 | - |
D-ribose | - |
Thermus aquaticus | |
| 151 | - |
D-arabinose | - |
Thermus aquaticus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | most effective activator of D-glucose isomerization | Thermus aquaticus | |
| Mg2+ | activates D-glucose isomerization, D-xylose isomerization and D-ribose isomerization | Thermus aquaticus | |
| Mn2+ | most effectively activates D-xylose isomerization | Thermus aquaticus | |
| Zn2+ | activates D-xylose isomerization | Thermus aquaticus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Thermus aquaticus | - |
- |
- |
| Thermus aquaticus HB8 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-Arabinose | - |
Thermus aquaticus | ? | - |
? | |
| D-Arabinose | - |
Thermus aquaticus HB8 | ? | - |
? | |
| D-Glucose | with low efficiency | Thermus aquaticus | D-Fructose | - |
? | |
| D-Glucose | with low efficiency | Thermus aquaticus HB8 | D-Fructose | - |
? | |
| D-Ribose | - |
Thermus aquaticus | ? | - |
? | |
| D-Ribose | - |
Thermus aquaticus HB8 | ? | - |
? | |
| D-Xylose | - |
Thermus aquaticus | D-Xylulose | - |
? | |
| D-Xylose | - |
Thermus aquaticus HB8 | D-Xylulose | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2.8 | - |
D-xylose | D-ribose | Thermus aquaticus | |
| 3 | - |
D-arabinose | - |
Thermus aquaticus | |
| 3.23 | - |
D-glucose | - |
Thermus aquaticus | |
| 7.7 | - |
D-xylulose | - |
Thermus aquaticus | |
| 8.6 | - |
D-xylose | - |
Thermus aquaticus | |
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