Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.3.1.24 extracted from

  • Cottier, V.; Barberis, A.; Luethi, U.
    Novel yeast cell-based assay to screen for inhibitors of human cytomegalovirus protease in a high-throughput format (2006), Antimicrob. Agents Chemother., 50, 565-571.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.3.1.24

Protein Variants

Protein Variants Comment Organism
additional information insertion of the cleavage sequence of human cytomegalovirus, HCMV, protease, which is an attractive target for antiviral drug development because of its essential function in viral replication, the enzyme serves as substrate for the protease in the screening assay for small molecule inhibitors of the protease, coexpression of HCMV protease with the engineered Trp1p substrate in yeast cells results in site-specific cleavage and functional inactivation of the Trp1p enzyme, thereby leading to an arrest of cell proliferation, this growth arrest can be suppressed by the addition of validated HCMV protease inhibitors, overview Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae the enzyme is essential for cell proliferation in the absence of tryptophan ?
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is essential for cell proliferation in the absence of tryptophan Saccharomyces cerevisiae ?
-
 ?

Synonyms

Synonyms Comment Organism
N-(5'-phosphoribosyl)anthranilate isomerase
-
 Saccharomyces cerevisiae
Trp1p
-
 Saccharomyces cerevisiae