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Literature summary for 5.3.1.24 extracted from

  • Huetter, R.; Niederberger, P.; DeMoss, J.A.
    Tryptophan biosynthetic genes in eukaryotic microorganisms (1986), Annu. Rev. Microbiol., 40, 55-77.
    View publication on PubMed
Search for more literature for 5.3.1.24

Cloned(Commentary)

Cloned (Comment) Organism
overview over trp/TRP genes encoding PRAI, functional organization of enzymes of tryptophan biosynthesis Escherichia coli
overview over trp/TRP genes encoding PRAI, functional organization of enzymes of tryptophan biosynthesis Saccharomyces cerevisiae
overview over trp/TRP genes encoding PRAI, functional organization of enzymes of tryptophan biosynthesis Aspergillus nidulans
overview over trp/TRP genes encoding PRAI, functional organization of enzymes of tryptophan biosynthesis Neurospora crassa
overview over trp/TRP genes encoding PRAI, functional organization of enzymes of tryptophan biosynthesis Schizosaccharomyces pombe
overview over trp/TRP genes encoding PRAI, functional organization of enzymes of tryptophan biosynthesis Coprinopsis lagopus
separate enzyme encoded by an independent gene, not associated with indole-3-glycerol-phosphate synthetase Saccharomyces cerevisiae
TRP1 gene encoding multifunctional enzyme is cloned in Escherichia coli and sequenced Neurospora crassa
TRP1 gene is cloned in Escherichia coli and sequenced Saccharomyces cerevisiae
TRPC gene encoding multifunctional enzyme is cloned in Escherichia coli and sequenced Aspergillus nidulans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-(5-phospho-beta-D-ribosyl)anthranilate Escherichia coli third step in tryptophan biosynthesis 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate Saccharomyces cerevisiae third step in tryptophan biosynthesis 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate Aspergillus nidulans third step in tryptophan biosynthesis 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate Neurospora crassa third step in tryptophan biosynthesis 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate Schizosaccharomyces pombe third step in tryptophan biosynthesis 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate Coprinopsis lagopus third step in tryptophan biosynthesis 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate Coprinopsis radiata third step in tryptophan biosynthesis 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate Escherichia coli involved in tryptophan biosynthesis from chorismate 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate Saccharomyces cerevisiae involved in tryptophan biosynthesis from chorismate 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate Aspergillus nidulans involved in tryptophan biosynthesis from chorismate 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate Neurospora crassa involved in tryptophan biosynthesis from chorismate 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate Schizosaccharomyces pombe involved in tryptophan biosynthesis from chorismate 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate Coprinopsis lagopus involved in tryptophan biosynthesis from chorismate 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate Coprinopsis radiata involved in tryptophan biosynthesis from chorismate 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Aspergillus nidulans
-
 multifunctional indole-3-glycerol-phosphate synthetase/PRA isomerase complex
-
Coprinopsis lagopus
-
-
-
Coprinopsis radiata
-
 multifunctional indole-3-glycerol-phosphate synthetase/PRA isomerase complex
-
Escherichia coli
-
-
-
Neurospora crassa
-
 multifunctional indole-3-glycerol-phosphate synthetase/PRA isomerase complex
-
Saccharomyces cerevisiae
-
 separate enzyme encoded by an independent gene, not associated with indole-3-glycerol-phosphate synthetase
-
Schizosaccharomyces pombe
-
 multifunctional indole-3-glycerol-phosphate synthetase/PRA isomerase complex
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-(5-phospho-beta-D-ribosyl)anthranilate
-
 Escherichia coli 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate
-
 Saccharomyces cerevisiae 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate
-
 Aspergillus nidulans 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate
-
 Neurospora crassa 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate
-
 Schizosaccharomyces pombe 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate
-
 Coprinopsis lagopus 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate
-
 Coprinopsis radiata 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate third step in tryptophan biosynthesis Escherichia coli 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate third step in tryptophan biosynthesis Saccharomyces cerevisiae 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate third step in tryptophan biosynthesis Aspergillus nidulans 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate third step in tryptophan biosynthesis Neurospora crassa 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate third step in tryptophan biosynthesis Schizosaccharomyces pombe 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate third step in tryptophan biosynthesis Coprinopsis lagopus 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate third step in tryptophan biosynthesis Coprinopsis radiata 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate involved in tryptophan biosynthesis from chorismate Escherichia coli 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate involved in tryptophan biosynthesis from chorismate Saccharomyces cerevisiae 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate involved in tryptophan biosynthesis from chorismate Aspergillus nidulans 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate involved in tryptophan biosynthesis from chorismate Neurospora crassa 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate involved in tryptophan biosynthesis from chorismate Schizosaccharomyces pombe 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate involved in tryptophan biosynthesis from chorismate Coprinopsis lagopus 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate involved in tryptophan biosynthesis from chorismate Coprinopsis radiata 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?

Subunits

Subunits Comment Organism
dimer active form Neurospora crassa