Literature summary for 5.3.1.13 extracted from

Bigham, E.C.; Gragg, Ch.E.; Hall, W.R.; Kelsey, J.E.; Mallory, W.R.; Richardson, C.B.; Benedict, C.; Ray, P.H.
Inhibition of arabinose 5-phosphate isomerase. An approach to the inhibition of bacterial lipopolysaccharide biosynthesis (1984), J. Med. Chem., 27, 717-726.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Erythronic acid 4-phosphate	best inhibitor	Escherichia coli
Phosphorylated sugars	in a series of nonphosphorylated sugars, the order of decreasing inhibitory activity is as follows: aldonic acids, alditols, aldoses	Escherichia coli

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.09	0.15	ribulose 5-phosphate	-	Escherichia coli
0.1	0.3	D-arabinose 5-phosphate	-	Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
135000	-	gel filtration	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Escherichia coli	key enzyme in synthesis of lipopolysaccharides	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
D-Arabinose 5-phosphate = D-ribulose 5-phosphate	mechanism is envisioned to involve an enediol intermediate	Escherichia coli	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-Arabinose 5-phosphate	r	Escherichia coli	D-Ribulose 5-phosphate	-	?
additional information	key enzyme in synthesis of lipopolysaccharides	Escherichia coli	?	-	?

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Release 2023.1 (January 2023)