Cloned (Comment) | Organism |
---|---|
- |
Trypanosoma cruzi |
Protein Variants | Comment | Organism |
---|---|---|
E26D/T27L/L28F/A30S/L100A/Q115A | mutant construcuted to produce a TIM with the inactivation susceptibility pattern of Trypanosoma brucei brucei enzyme, shows a similar resistance pattern to the inactivation with methylmethane thiosulfonate as wild-type Trypanosoma brucei brucei TIM | Trypanosoma cruzi |
E26D/T27L/L28F/A30S/T32S/L100A/Q115A | mutant construcuted to produce a TIM with the inactivation susceptibility pattern of Trypanosoma brucei brucei enzyme, shows a similar resistance pattern to the inactivation with methylmethane thiosulfonate as wild-type Trypanosoma brucei brucei TIM | Trypanosoma cruzi |
E26D/T27L/L28F/L100A/Q115A | mutant construcuted to produce a TIM with the inactivation susceptibility pattern of Trypanosoma brucei brucei enzyme, shows a similar resistance pattern to the inactivation with methylmethane thiosulfonate as wild-type Trypanosoma brucei brucei TIM | Trypanosoma cruzi |
F28L/A100L/A115Q | mutant constructed to mimick the methylmethane sulfonate inactivation pattern of the Trypanosoma cruzi enzyme. Protein is similarly susceptibel to methylmethane sulfonate as the Trypanosoma cruzi enzyme | Trypanosoma brucei brucei |
L28F/L100A/Q115A | mutant construcuted to produce a TIM with the inactivation susceptibility pattern of Trypanosoma brucei brucei enzyme. Protein is more resistant to the inactivation with methylmethane thiosulfonate as wild-type | Trypanosoma cruzi |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
methylmethane thiosulfonate | inactivation by sulfhydroxylation | Trypanosoma brucei brucei | |
methylmethane thiosulfonate | inactivation by sulfhydroxylation | Trypanosoma cruzi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei brucei | P04789 | - |
- |
Trypanosoma cruzi | P52270 | - |
- |