Literature summary for 5.3.1.1 extracted from

Aguilera, E.; Varela, J.; Birriel, E.; Serna, E.; Torres, S.; Yaluff, G.; de Bilbao, N.; Aguirre-Lopez, B.; Cabrera, N.; Diaz Mazariegos, S.; de Gomez-Puyou, M.; Gomez-Puyou, A.; Perez-Montfort, R.; Minini, L.; Merlino, A.; Cerecetto, H.; Gonzalez, M.; Alvarez, G.
Potent and selective inhibitors of Trypanosoma cruzi triosephosphate isomerase with concomitant inhibition of cruzipain Inhibition of parasite growth through multitarget activity (2016), ChemMedChem, 17, 1328-1338 .

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Trypanosoma cruzi

Crystallization (Comment)	Organism
molecular docking studies with inhibitors	Trypanosoma cruzi

Inhibitors	Comment	Organism
(1E,3E,6E,8E)-1,9-di(furan-2-yl)nona-1,3,6,8-tetraen-5-one	compound binds to the dimer interface and is unable to inactivate Trypanosoma brucei TIM or Homo sapiens TIM at concentrations higher than 100 microM. Compound also affects cruzipain	Trypanosoma cruzi
(2E,5E)-2,5-bis[(2E)-3-(thiophen-2-yl)prop-2-en-1-ylidene]cyclopentan-1-one	compound is unable to inactivate Trypanosoma brucei TIM or Homo sapiens TIM at concentrations higher than 100 microM. Compound also affects cruzipain	Trypanosoma cruzi
(2E,6E)-2,6-bis[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]cyclohexan-1-one	compound binds to the dimer interface and is unable to inactivate Trypanosoma brucei TIM or Homo sapiens TIM at concentrations higher than 100 microM. Compound also affects cruzipain	Trypanosoma cruzi

Organism	UniProt	Comment	Textmining
Trypanosoma cruzi	-	-	-
Trypanosoma cruzi Tulahuen 2	-	-	-

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.000086	-	pH 7.4, 25°C	Trypanosoma cruzi	(2E,6E)-2,6-bis[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]cyclohexan-1-one
0.003	-	pH 7.4, 25°C	Trypanosoma cruzi	(1E,3E,6E,8E)-1,9-di(furan-2-yl)nona-1,3,6,8-tetraen-5-one
0.0047	-	pH 7.4, 25°C	Trypanosoma cruzi	(2E,5E)-2,5-bis[(2E)-3-(thiophen-2-yl)prop-2-en-1-ylidene]cyclopentan-1-one