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Literature summary for 5.3.1.1 extracted from
- Schistosoma mansoni triose phosphate isomerase peptide MAP4 is able to trigger naive donor immune response towards a type-1 cytokine profile (2008), Scand. J. Immunol., 68, 169-176.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | evaluation of the ability of naive monocyte-derived dendritic cells to sensitize peripheral blood mononuclear cells to the Schistosoma vaccine candidate MAP4 using a priming in vitro assay. MAP4 is a multiple antigen peptide containing B- and T-cell epitopes derived from the enzyme triose phosphate isomerase. Cytokine production from activated MAP4 priming in vitro cells is predominantly Th1-like, consisting mainly of IFN-gamma. Naive donor dendritic cells, sensitized with MAP4, thus are able to prime and clonally expand MAP4-specific T cells towards a Th1-type response | Schistosoma mansoni |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Schistosoma mansoni | - |
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