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Literature summary for 5.3.1.1 extracted from

  • Olivares-Illana, V.; Perez-Montfort, R.; Lopez-Calahorra, F.; Costas, M.; Rodriguez-Romero, A.; Tuena de Gomez-Puyou, M.; Gomez Puyou, A.
    Structural differences in triosephosphate isomerase from different species and discovery of a multitrypanosomatid inhibitor (2006), Biochemistry, 45, 2556-2560.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,2'-methylenebis(1,3-benzothiazole) irreversible inactivation Leishmania mexicana
2,2'-methylenebis(1,3-benzothiazole) irreversible inactivation Trypanosoma brucei
2,2'-methylenebis(1,3-benzothiazole) 40% inactivation at 0.05 mM, irreversible Trypanosoma cruzi
6,6'-bi-1,3-benzothiazole-2,2'-diamine irreversible inactivation. Not inhibitory on human, yeast, chicken, Plasmodium falciparum, and Entamoeba histolytica enzyme Leishmania mexicana
6,6'-bi-1,3-benzothiazole-2,2'-diamine irreversible inactivation. Not inhibitory on human, yeast, chicken, Plasmodium falciparum, and Entamoeba histolytica enzyme Trypanosoma brucei
6,6'-bi-1,3-benzothiazole-2,2'-diamine 91% inactivation at 0.05 mM, irreversible. Not inhibitory on human, yeast, chicken, Plasmodium falciparum, and Entamoeba histolytica enzyme Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Leishmania mexicana
-
-
-
Trypanosoma brucei
-
-
-
Trypanosoma cruzi
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-