Literature summary for 5.2.1.8 extracted from

Wiemels, R.; Cech, S.; Meyer, N.; Burke, C.; Weiss, A.; Parks, A.; Shaw, L.; Carroll, R.
An intracellular peptidyl-prolyl cis/ trans isomerase is required for folding and activity of the Staphylococcus aureus secreted virulence factor nuclease (2017), J. Bacteriol., 199, e00453 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
cyclosporine A	-	Staphylococcus aureus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Staphylococcus aureus	5829	-

Organism

Organism	UniProt	Comment	Textmining
Staphylococcus aureus	Q2FFQ5	-	-
Staphylococcus aureus	Q2FIC1	-	-
Staphylococcus aureus USA300	Q2FFQ5	-	-
Staphylococcus aureus USA300	Q2FIC1	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(cis)-Pro residue in nuclease Nuc	-	Staphylococcus aureus	(trans)-Pro residue in nuclease Nuc	-	r
(cis)-Pro residue in nuclease Nuc	-	Staphylococcus aureus USA300	(trans)-Pro residue in nuclease Nuc	-	r
N-succinyl-Ala-Ala-Phe-(cis)-Pro-4-nitroanilide	-	Staphylococcus aureus	N-succinyl-Ala-Ala-Phe-(trans)-Pro-4-nitroanilide	-	r
N-succinyl-Ala-Ala-Phe-(cis)-Pro-4-nitroanilide	-	Staphylococcus aureus USA300	N-succinyl-Ala-Ala-Phe-(trans)-Pro-4-nitroanilide	-	r

Synonyms

Synonyms	Comment	Organism
PpiB	-	Staphylococcus aureus
PrsA	-	Staphylococcus aureus
SAUSA300_0857	-	Staphylococcus aureus

General Information

General Information	Comment	Organism
physiological function	deletion of PrsA leads to a decrease in secreted protease and phospholipase activity. Deletion does not alter the growth characteristics of Staphylococcus aureus	Staphylococcus aureus
physiological function	disruption of ppiB does not alter the growth characteristics of the strains but results in decreased activity of secreted virulence factor nuclease Nuc in culture supernatants, probably resulting from misfolding of Nuc in the absence of PpiB. Ppib directly interacts with Nuc in vitro	Staphylococcus aureus

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Release 2023.1 (January 2023)