Literature summary for 5.2.1.8 extracted from

Jalouli, M.; Dery, M.A.; Lafleur, V.N.; Lamalice, L.; Zhou, X.Z.; Lu, K.P.; Richard, D.E.
The prolyl isomerase Pin1 regulates hypoxia-inducible transcription factor (HIF) activity (2014), Cell. Signal., 26, 1649-1656 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q13526	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(cis)-Pro residue in HIF-1alpha	-	Homo sapiens	(trans)-Pro residue in HIF-1alpha	-	r

General Information

General Information	Comment	Organism
physiological function	Pin1 interacts with hypoxia-inducible transcription factor HIF-1alpha. The interaction is regulated through p42/p44 MAPK pathway activation, and Pin1 catalytic activity generates a conformational change in HIF-1alpha. Pin1 is required for gene-specific HIF-1 transcriptional activity	Homo sapiens

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Release 2023.1 (January 2023)