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Literature summary for 5.2.1.8 extracted from
- Prolyl isomerase Pin1 promotes proplatelet formation of megakaryocytes via tau (2017), Biochem. Biophys. Res. Commun., 493, 946-951 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q9QUR7 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (cis)-Pro in microtubule associated protein tau | - |
Mus musculus | (trans)-Pro in microtubule associated protein tau | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Pin1 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | mice lacking the Pin1 gene form more megakaryocytes than wild type mice, and the proplatelet formation of megakaryocytes is poorer in Pin1-/- mice than in wild-type mice. Treatment of megakaryoblastic floating cell line Meg-01 with shRNA against Pin1 suppresses the proplatelet formation. Expression of tau, a microtubule associated protein is induced in megakaryocytes during proplatelet formation. Pin1 binds tau and promotes microtubule polymerization | Mus musculus |
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