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Literature summary for 5.2.1.8 extracted from

  • Ingelsson, B.; Shapiguzov, A.; Kieselbach, T.; Vener, A.V.
    Peptidyl-prolyl isomerase activity in chloroplast thylakoid lumen is a dispensable function of immunophilins in Arabidopsis thaliana (2009), Plant Cell Physiol., 50, 1801-1814.
    View publication on PubMed
Search for more literature for 5.2.1.8

Protein Variants

Protein Variants Comment Organism
additional information construction of DNA T-insertion mutants. PPIase activity in the thylakoid lumen of the mutants lacking either AtFKBP13 or both AtFKBP13 and AtCYP20-2 is 10% and 2%, respectively, of wild-type activity. Residual PPIase activity detected in the double mutant originates from AtCYP20-3. None of the mutants differs from the wild-type plants when grown under normal, cold stress or high light conditions Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
cyclosporin A
-
 Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast stroma and lumen Arabidopsis thaliana 9507
-
chloroplast stroma CYP20-3 Arabidopsis thaliana 9570
-
thylakoid lumen, CYP20-2 and FKBP13 Arabidopsis thaliana 9579
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Arabidopsis thaliana AtFKBP13 and AtCYP20-2 possess peptidyl-prolyl cis/trans isomerase activity and might be involved in protein folding catalysis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q9SCY2 FKBP13
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme partially by chlorplast thylakoid preparation Arabidopsis thaliana

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information AtFKBP13 and AtCYP20-2 possess peptidyl-prolyl cis/trans isomerase activity and might be involved in protein folding catalysis Arabidopsis thaliana ?
-
 ?
Suc-Ala-Ala-cis-Pro-Phe-4-nitroanilide cis/trans-isomerization Arabidopsis thaliana Suc-Ala-Ala-trans-Pro-Phe-4-nitroanilide
-
 ?
Suc-Ala-Leu-cis-Pro-Phe-4-nitroanilide cis/trans-isomerization Arabidopsis thaliana Suc-Ala-Leu-trans-Pro-Phe-4-nitroanilide
-
 ?

Synonyms

Synonyms Comment Organism
CYP20-2 i.e. cyclophilin 20-2 Arabidopsis thaliana
CYP20-3 i.e. cyclophilin 20-3 Arabidopsis thaliana
FKBP13 i.e. FK506-binding protein 13 Arabidopsis thaliana
peptidyl-prolyl isomerase
-
 Arabidopsis thaliana
PPIase
-
 Arabidopsis thaliana