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Literature summary for 5.2.1.8 extracted from

  • Shen, Z.J.; Esnault, S.; Schinzel, A.; Borner, C.; Malter, J.S.
    The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation (2009), Nat. Immunol., 10, 257-265.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.2.1.8

Activating Compound

Activating Compound Comment Organism Structure
additional information GM-CSF-induced activation of Erk1/2, which phosphorylated Thr167 of the pro-apoptotic Bcl-2-associated X protein, Bax, facilitates de novo interaction of Bax with the prolyl isomerase Pin1 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
juglone i.e. 5-hydroxy-1,4-naphthoquinone, selective and irreversible inhibition. Juglone reduces PPIase activity but does not alter Pin1 expression Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphorylated pro-apoptotic Bcl-2-associated X protein Homo sapiens Pin1 prevents activation of Bax, prevents Bax cleavage by calpain, and prevents Bax translocation to mitochondria ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
eosinophil primary Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated pro-apoptotic Bcl-2-associated X protein Pin1 prevents activation of Bax, prevents Bax cleavage by calpain, and prevents Bax translocation to mitochondria Homo sapiens ?
-
 ?
phosphorylated pro-apoptotic Bcl-2-associated X protein i.e. Bax Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
peptidyl-prolyl isomerase
-
 Homo sapiens
Pin1
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction Pin1 blockade leads to Bax cleavage, mitochondrial translocation and caspase 9 and 3 activation, irrespective of the presence of cytokines, and Pin1 blockade accelerates eosinophil apoptosis Homo sapiens
physiological function Pin1 is a key mediator of pro-survival signaling and a regulator of the pro-apoptotic Bcl-2-associated X protein, Bax, function. Pin1 likely functions as a downstream effector of GM-CSF and IL-5 signaling, and regulates cell death through the intrinsic, mitochondria- and caspase 9-dependent, apoptotic pathway, overview Homo sapiens