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Literature summary for 5.2.1.8 extracted from

  • van der Horst, A.; Khanna, K.K.
    The peptidyl-prolyl isomerase Pin1 regulates cytokinesis through Cep55 (2009), Cancer Res., 69, 6651-6659.
    View publication on PubMed
Search for more literature for 5.2.1.8

Protein Variants

Protein Variants Comment Organism
additional information depletion of Pin1 from HeLa cells causes a cytokinesis defect, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information in mitotic cells, Pin1 is located in the midbody ring Homo sapiens
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-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens Pin1 enhances Plk1-mediated phosphorylation of the centrosome protein Cep55, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
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HEK-293T cell
-
 Homo sapiens
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HeLa cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Pin1 enhances Plk1-mediated phosphorylation of the centrosome protein Cep55, overview Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
peptidyl-prolyl isomerase
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 Homo sapiens
Pin1
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 Homo sapiens

General Information

General Information Comment Organism
malfunction Pin1 is deregulated in many tumors Homo sapiens
physiological function the Pin1 is located in the midbody ring in HeLa cells and regulates cell cycle progression and cytokinesis through centrosome protein Cep55, which is an essential component of the midbody ring Homo sapiens