Literature summary for 5.2.1.8 extracted from

Buschdorf, J.P.; Chew, L.L.; Soh, U.J.; Liou, Y.C.; Low, B.C.
Nerve growth factor stimulates interaction of Cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neurons (2008), PLoS ONE, 3, e2686.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in 293-T cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
C113A	mutation in isomerase domain, catalytically inert. Mutation diminishes binding to brain-specifc protein BNIP-H	Homo sapiens
S16A	mutation in WW domain. Mutation diminishes binding to brain-specifc protein BNIP-H	Homo sapiens
S16E	mutation in WW domain. Mutation diminishes binding to brain-specifc protein BNIP-H	Homo sapiens
W34A	mutation in WW domain. Mutation diminishes binding to brain-specifc protein BNIP-H	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Subunits

Subunits	Comment	Organism
More	isoform Pin1 interacts with brain-specifc protein BNIP-H after nerve growth factor stimulation. Both proteins co-localize in the neurites and cytosol of differentiating pheochromocytoma PC12 cells and the embryonic carcinoma P19 cells. Expression of Pin1 disrupts the BNIP-H/glutaminase complex formation in PC-12 cells under nerve growth factor-stimulation	Homo sapiens

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Release 2023.1 (January 2023)