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Literature summary for 5.2.1.8 extracted from

  • Braun, M.; Hessamian-Alinejad, A.; de Lacroix, B.F.; Alvarez, B.H.; Fischer, G.
    Novel spiroannulated 3-benzofuranones. Synthesis and inhibition of the human peptidyl prolyl cis/trans isomerase Pin1 (2008), Molecules, 13, 995-1003.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.2.1.8

Inhibitors

Inhibitors Comment Organism Structure
5-methoxy-1',3'dihydro-3H-spiro[1-benzofuran-2,2'-indene]-3-one
-
 Homo sapiens
5-methoxy-2',3'-dihydro-3H-spiro[1-benzofuran-2,1'-indene]-3-one
-
 Homo sapiens
5-methoxy-3H-spiro[1-benzofuran-2,1'-cyclopent[3]en]-3-one
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isoform Pin1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
suc-Ala-Glu-(cis)-Pro-Phe-4-nitroanilide
-
 Homo sapiens suc-Ala-Glu-(trans)-Pro-Phe-4-nitroanilide
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.065
-
-
 Homo sapiens 5-methoxy-3H-spiro[1-benzofuran-2,1'-cyclopent[3]en]-3-one
0.077
-
-
 Homo sapiens 5-methoxy-2',3'-dihydro-3H-spiro[1-benzofuran-2,1'-indene]-3-one
0.1
-
-
 Homo sapiens 5-methoxy-1',3'dihydro-3H-spiro[1-benzofuran-2,2'-indene]-3-one