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Literature summary for 5.2.1.8 extracted from

  • Kim, J.; Choi, T.G.; Ding, Y.; Kim, Y.; Ha, K.S.; Lee, K.H.; Kang, I.; Ha, J.; Kaufman, R.J.; Lee, J.; Choe, W.; Kim, S.S.
    Overexpressed cyclophilin B suppresses apoptosis associated with ROS and Ca2+ homeostasis after ER stress (2008), J. Cell Sci., 121, 3636-3648.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression in H9C2 cell Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information overexpression of wild-type isoform CypB attenuates endoplasmic reticulum stress-induced cell death, whereas overexpression of isomerase activity-defective mutant R62A increases Ca2+ leakage from the endoplasmic reticulum and generation of reactive oxygen species and decreases mitochondrial membrane potential resulting in cell death. siRNA-mediated inhibition of CypB expression renders cells more vulnerable to endoplasmic reticulum stress. CypB interacts with the endoplasmic reticulum stress-related chaperones, Bip and Grp94 Rattus norvegicus
R62A overexpression of wild-type isoform CypB attenuates endoplasmic reticulum stress-induced cell death, whereas overexpression of isomerase activity-defective mutant R62A increases Ca2+ leakage from the endoplasmic reticulum and generation of reactive oxygen species and decreases mitochondrial membrane potential resulting in cell death Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Subunits

Subunits Comment Organism
More CypB interacts with the endoplasmic reticulum stress-related chaperones, Bip and Grp94 Rattus norvegicus