Literature summary for 5.2.1.8 extracted from

Davis, T.L.; Walker, J.R.; Ouyang, H.; MacKenzie, F.; Butler-Cole, C.; Newman, E.M.; Eisenmesser, E.Z.; Dhe-Paganon, S.
The crystal structure of human WD40 repeat-containing peptidylprolyl isomerase (PPWD1) (2008), FEBS J., 275, 2283-2295.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
1.65 A resolution. The N-terminus of one isomerase domain is bound in the active site of a neighbouring isomerase molecule in a manner analogous to the substrate. This sequence binds to the active site of the enzyme, but cannot be turned over	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
QAEGPK	peptide corresponding to peptide QAEGP487KR at the N-terminus of the enzyme's isomerase domain. Peptide binds to the active site, but the enzyme does not catalyze its isomerization	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q96BP3	peptidylprolyl isomerase containing WD40 repeat	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-succinyl-Ala-Ala-(trans)-Pro-Phe-4-nitroanilide	-	Homo sapiens	N-succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilide	-	?

Synonyms

Synonyms	Comment	Organism
PPWD1	-	Homo sapiens

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Release 2023.1 (January 2023)