Protein Variants | Comment | Organism |
---|---|---|
H157A | mutant supports viability in yeast complementation assay | Homo sapiens |
H157F | mutant supports viability in yeast complementation assay | Homo sapiens |
H157L | mutant supports viability in yeast complementation assay | Homo sapiens |
H157N | mutant supports viability in yeast complementation assay | Homo sapiens |
H157S | mutant supports viability in yeast complementation assay | Homo sapiens |
H59A | mutant supports viability in yeast complementation assay | Homo sapiens |
H59F | mutant supports viability in yeast complementation assay but displays significantly reduced growth in yeast compared to wild-type Pin1 | Homo sapiens |
H59L | mutant is not viable | Homo sapiens |
H59L/H157A | about 50% of wild-type activity with substrate Trp-Phe-Tyr-Ser(PO3H2)-(cis)-Pro-Arg-4-nitroanilide, no activity with substrate Ala-Glu-(cis)-Pro-Phe-4-nitroanilide | Homo sapiens |
H59L/H157F | about 5% of wild-type activity with substrate Trp-Phe-Tyr-Ser(PO3H2)-(cis)-Pro-Arg-4-nitroanilide, 3% activity with substrate Ala-Glu-(cis)-Pro-Phe-4-nitroanilide | Homo sapiens |
H59L/H157L | mutant supports viability in yeast complementation assay, mutation H157L rescues mutant H59L | Homo sapiens |
H59L/H157S | about 5% of wild-type activity with substrate Trp-Phe-Tyr-Ser(PO3H2)-(cis)-Pro-Arg-4-nitroanilide, no activity with substrate Ala-Glu-(cis)-Pro-Phe-4-nitroanilide | Homo sapiens |
H59N | mutant supports viability in yeast complementation assay | Homo sapiens |
H59S | mutant supports viability in yeast complementation assay | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoform Pin1 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ala-Glu-(cis)-Pro-Phe-4-nitroanilide | - |
Homo sapiens | Ala-Glu-(trans)-Pro-Phe-4-nitroanilide | - |
? | |
Trp-Phe-Tyr-Ser(PO3H2)-(cis)-Pro-Arg-4-nitroanilide | - |
Homo sapiens | Trp-Phe-Tyr-Ser(PO3H2)-(trans)-Pro-Arg-4-nitroanilide | - |
? |