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Literature summary for 5.2.1.8 extracted from

  • Monaghan, P.; Bell, A.
    A Plasmodium falciparum FK506-binding protein (FKBP) with peptidyl-prolyl cis-trans isomerase and chaperone activities (2005), Mol. Biochem. Parasitol., 139, 185-195.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
FK506 50% inhibition at 0.00032 mM Plasmodium falciparum
additional information cyclosporin A is not inhibitory up to 0.005 mM Plasmodium falciparum
Rapamycin 50% inhibition at 0.00048 mM Plasmodium falciparum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34800
-
x * 34800, calculated Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Plasmodium falciparum enzyme inhibits the phosphatase activity of calcineurin independently of FK506 binding. Enzyme also inhibits thermal aggregation of two model substrates indicating chaperone proterties ?
-
?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme inhibits the phosphatase activity of calcineurin independently of FK506 binding. Enzyme also inhibits thermal aggregation of two model substrates indicating chaperone proterties Plasmodium falciparum ?
-
?
succinyl-Ala-Leu-(cis)-Pro-Phe-p-nitroanilide
-
Plasmodium falciparum succinyl-Ala-Leu-(trans)-Pro-Phe-p-nitroanilide
-
?

Subunits

Subunits Comment Organism
? x * 34800, calculated Plasmodium falciparum

Synonyms

Synonyms Comment Organism
FKBP35
-
Plasmodium falciparum