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Literature summary for 5.2.1.2 extracted from
- Maleylacetone cis-trans-isomerase: affinity chromatography on glutathione-bound Sepharose. Two-substrate-binding sequence from inhibition patterns (1976), Biochemistry, 15, 4228-4233.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| GSH | the enzyme binds glutathione through the backbone of the tripeptide | Vibrio sp. |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| GSSG | - |
Vibrio sp. | |
| S-Methylglutathione | - |
Vibrio sp. | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.14 | - |
GSH | - |
Vibrio sp. | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Vibrio sp. | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Vibrio sp. |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| 4-Maleylacetoacetate = 4-fumarylacetoacetate | ordered sequence of binding: maleylacetone first followed by glutathione | Vibrio sp. |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (+/-)-2-bromo-3-(4-nitrophenyl)propionic acid + glutathione | - |
Vibrio sp. | 2-(glutathion-S-yl)-3-(4-nitrophenyl)propanoic acid | - |
? | |
| Maleylacetoacetate | - |
Vibrio sp. | Fumarylacetoacetate | - |
? | |
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