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Literature summary for 5.1.99.4 extracted from

  • Woodman, T.J.; Wood, P.J.; Thompson, A.S.; Hutchings, T.J.; Steel, G.R.; Jiao, P.; Threadgill, M.D.; Lloyd, M.D.
    Chiral inversion of 2-arylpropionyl-CoA esters by human alpha-methylacyl-CoA racemase 1A (P504S)-a potential mechanism for the anti-cancer effects of ibuprofen (2011), Chem. Commun. (Camb. ), 47, 7332-7334.
    View publication on PubMed
Search for more literature for 5.1.99.4

Application

Application Comment Organism
medicine reduction of AMACR activity is proposed as a treatment for prostate and other cancers Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.052
-
 (S)-ketoprofenoyl-CoA pH and temperature not specified in the publication Homo sapiens
0.068
-
 (S)-naproxenoyl-CoA pH and temperature not specified in the publication Homo sapiens
0.277
-
 (2S)-2-methyldecanoyl-CoA pH and temperature not specified in the publication Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-fenoprofenoyl-CoA best substrate Homo sapiens (S)-fenoprofenoyl-CoA
-
 ?
(R)-ibuprofenoyl-CoA
-
 Homo sapiens (S)-ibuprofenoyl-CoA
-
 ?
(S)-2-methyldecanoyl-CoA
-
 Homo sapiens (R)-2-methyldecanoyl-CoA
-
 ?
(S)-ketoprofenoyl-CoA
-
 Homo sapiens (R)-ketoprofenoyl-CoA
-
 ?
(S)-naproxenoyl-CoA
-
 Homo sapiens (R)-naproxenoyl-CoA
-
 ?
flurbiprofenoyl-CoA
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
alpha-methylacyl-CoA racemase 1A
-
 Homo sapiens
AMACR 1A
-
 Homo sapiens
ibuprofenoyl-CoA epimerase
-
 Homo sapiens
P504S
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0095
-
 (S)-naproxenoyl-CoA pH and temperature not specified in the publication Homo sapiens
0.015
-
 (S)-ketoprofenoyl-CoA pH and temperature not specified in the publication Homo sapiens
0.031
-
 (2S)-2-methyldecanoyl-CoA pH and temperature not specified in the publication Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.112
-
 (2S)-2-methyldecanoyl-CoA pH and temperature not specified in the publication Homo sapiens
0.14
-
 (S)-naproxenoyl-CoA pH and temperature not specified in the publication Homo sapiens
0.29
-
 (S)-ketoprofenoyl-CoA pH and temperature not specified in the publication Homo sapiens