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Literature summary for 5.1.99.4 extracted from

  • Honma, I.; Torigoe, T.; Hirohashi, Y.; Kitamura, H.; Sato, E.; Masumori, N.; Tamura, Y.; Tsukamoto, T.; Sato, N.
    Aberrant expression and potency as a cancer immunotherapy target of alpha-methylacyl-coenzyme A racemase in prostate cancer (2009), J. Transl. Med., 7, 103.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.1.99.4

Application

Application Comment Organism
drug development AMACR can be an attractive target for cytotoxic T-lymphocyte-based immunotherapy for cancer Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-
peroxisome
-
 Homo sapiens 5777
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
DU-145 cell prostate cancer cell line Homo sapiens
-
LNCaP cell prostate cancer cell line Homo sapiens
-
PC-3 cell prostate cancer cell line Homo sapiens
-

Synonyms

Synonyms Comment Organism
alpha-methylacyl-CoA racemase
-
 Homo sapiens
AMACR
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme is strongly expressed in prostate cancer cell lines and tissues as compared with benign or normal prostate tissues, furthermore, enzyme is expressed abundantly in colorectal cancer, lung cancer tissues, renal and hepatic cancer, whereas it is barely detected in benign tissues and normal prostate epithelial cells up

General Information

General Information Comment Organism
physiological function enzyme catalyzes the racemization of alpha-methyl carboxylic coenzyme A thioesters in mitochondria and peroxisomes, induction of AMACR-specific cytotoxic mononuclear cells from prostate cancer patients peripheral blood mononuclear cells Homo sapiens