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Literature summary for 5.1.99.4 extracted from

  • Schmitz, W.; Fingerhut, R.; Conzelmann, E.
    Purification and properties of an alpha-methylacyl-CoA racemase from rat liver (1994), Eur. J. Biochem., 222, 313-323.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
palmitoyl-CoA stimulates at low concentrations, inhibits above 0.1 mM Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide
-
Rattus norvegicus
2-(4-Isobutylphenyl)propionic acid i.e. ibuprofen, strongest of all competitive inhibitors tested Rattus norvegicus
2-methylmyristoyl-CoA inhibits reaction with 2-pristanoyl-CoA Rattus norvegicus
2-methyloctanoyl-CoA inhibits reaction with 2-pristanoyl-CoA Rattus norvegicus
5,5'-dithiobis(2-nitrobenzoate) inhibition is reversed by incubation of the inactivated enzyme with 10 mM dithiothreitol Rattus norvegicus
Cu2+
-
Rattus norvegicus
diethylpyrocarbonate
-
Rattus norvegicus
diisopropylphosphofluoridate
-
Rattus norvegicus
Fe2+ slight inhibition Rattus norvegicus
Hg2+
-
Rattus norvegicus
additional information no inhibition by iodoacetamide Rattus norvegicus
NEM weak Rattus norvegicus
palmitoyl-CoA stimulates at low concentrations, inhibits above 0.1 mM Rattus norvegicus
thimerosal slight Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.06
-
trihydroxycoprostanoyl-CoA
-
Rattus norvegicus
0.076
-
pristanoyl-CoA
-
Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
44700
-
gel filtration Rattus norvegicus
44900
-
1 * 44900, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
development of a very sensitive and convenient radiometric assay Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-2-Methylmyristoyl-CoA r Rattus norvegicus (R)-2-Methylmyristoyl-CoA
-
?
(S)-Pristanoyl-CoA r Rattus norvegicus (R)-Pristanoyl-CoA
-
?
(S)-Trihydroxycoprostanoyl-CoA r Rattus norvegicus (R)-Trihydroxycoprostanoyl-CoA
-
?
additional information no activity with 3-methyl-branched or linear-chain acyl-CoAs Rattus norvegicus ?
-
?
pristanoyl-CoA
-
Rattus norvegicus ?
-
?

Subunits

Subunits Comment Organism
monomer 1 * 44900, SDS-PAGE Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
pristanoyl-CoA Rattus norvegicus
7
-
trihydroxycoprostanoyl-CoA Rattus norvegicus