Protein Variants | Comment | Organism |
---|---|---|
additional information | targeted deletion of ugeA resulting in a severe reduction of galactofuranose in N-linked glucans | Aspergillus niger |
N191D | naturally occuring mutation, the UgeA mutant shows reduced galactofuranose production, the mutant enzyme is partially active | Aspergillus niger |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell wall | - |
Aspergillus niger | 5618 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucose | Aspergillus niger | - |
UDP-galactose | - |
r | |
UDP-glucose | Aspergillus niger CBS 513.88 / FGSC A1513 | - |
UDP-galactose | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aspergillus niger | A2R3C7 | - |
- |
Aspergillus niger CBS 513.88 / FGSC A1513 | A2R3C7 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucose | - |
Aspergillus niger | UDP-galactose | - |
r | |
UDP-glucose | - |
Aspergillus niger CBS 513.88 / FGSC A1513 | UDP-galactose | - |
r |
Synonyms | Comment | Organism |
---|---|---|
An14g03820 | - |
Aspergillus niger |
UDP-glucose-4-epimerase | - |
Aspergillus niger |
UgeA | - |
Aspergillus niger |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Aspergillus niger |
General Information | Comment | Organism |
---|---|---|
evolution | presence of three putative UDP glucose-4-epimerases, UgeA, UgeB, and UgeC, in Aspergillus niger, encoded by genes An14g03820, An12g10410, and An02g11320. Enzyme UgeA belongs to the NAD(P)-dependent epimerase/dehydratase family | Aspergillus niger |
malfunction | mutation of enzyme UgeA results in reduced galactofuranose production, deletion of gene ugeA abolishes the galactofuranose production | Aspergillus niger |
physiological function | enzyme UgeA is required for the biosynthesis of galactofuranose as well as for galactose metabolism in Aspergillus niger. UgeA is required for growth on galactose in Aspergillus niger | Aspergillus niger |