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Literature summary for 5.1.3.19 extracted from

  • Gouignard, N.; Schoen, T.; Holmgren, C.; Strate, I.; Tasoez, E.; Wetzel, F.; Maccarana, M.; Pera, E.
    Gene expression of the two developmentally regulated dermatan sulfate epimerases in the Xenopus embryo (2018), PLoS ONE, 13, e0191751 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.1.3.19

Cloned(Commentary)

Cloned (Comment) Organism
gene dse, located on chromosome 5S, genetic structure, quantitative enzyme real-time PCR expression analysis Xenopus laevis
gene dsel, located on chromosome 5L, genetic structure, quantitative enzyme real-time PCR expression analysis Xenopus laevis

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane two transmembrane segments Xenopus laevis 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Chondroitin D-glucuronate Xenopus laevis
-
 Dermatan L-iduronate
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 r

Organism

Organism UniProt Comment Textmining
Xenopus laevis A0A166W7U1
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-
Xenopus laevis B1H189
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-

Source Tissue

Source Tissue Comment Organism Textmining
adenohypophysis fetal Xenopus laevis
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brain fetal Xenopus laevis
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dermatome fetal Xenopus laevis
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dorsal endoderm fetal Xenopus laevis
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embryo enzyme Dse is maternally expressed and exhibits partially overlapping activity with enzyme Dsel in the eyes, brain, trigeminal ganglia, neural crest, adenohypophysis, sclerotome, and dorsal endoderm. Dse is specifically expressed in the epidermis, anterior surface ectoderm, spinal nerves, notochord and dermatome, quantitative enzyme real-time PCR expression analysis of different development al stages of the embryo, overview Xenopus laevis
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embryo enzyme Dsel is maternally expressed and exhibits partially overlapping activity with enzyme Dse in the eyes, brain, trigeminal ganglia, neural crest, adenohypophysis, sclerotome, and dorsal endoderm. Dsel mRNA alone is transcribed in the spinal cord, epibranchial ganglia, prechordal mesendoderm, and myotome, quantitative enzyme real-time PCR expression analysis of different development al stages of the embryo, overview Xenopus laevis
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epibranchial ganglion fetal Xenopus laevis
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epidermis fetal Xenopus laevis
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eye fetal Xenopus laevis
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myotome fetal Xenopus laevis
-
neural crest fetal Xenopus laevis
-
notochord fetal Xenopus laevis
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prechordal mesendoderm fetal Xenopus laevis
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sclerotome fetal Xenopus laevis
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spinal cord fetal Xenopus laevis
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spinal nerve fetal Xenopus laevis
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surface ectoderm fetal Xenopus laevis
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trigeminal ganglion fetal Xenopus laevis
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Chondroitin D-glucuronate
-
 Xenopus laevis Dermatan L-iduronate
-
 r

Synonyms

Synonyms Comment Organism
dermatan sulfate epimerase
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 Xenopus laevis
dermatan sulfate epimerase-2
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 Xenopus laevis
DS epimerase 1
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 Xenopus laevis
DS epimerase 2
-
 Xenopus laevis
DS-epi1
-
 Xenopus laevis
DS-epi2
-
 Xenopus laevis
DSE
-
 Xenopus laevis
DSEL
-
 Xenopus laevis

General Information

General Information Comment Organism
additional information enzyme Dsel harbors a C-terminal sulfotransferase-like domain Xenopus laevis
physiological function the enzyme converts chondroitin sulfate (CS) to a CS/dermatan sulfate (DS) hybrid chain, which is structurally and conformationally richer than CS, favouring interaction with matrix proteins and growth factors Xenopus laevis
physiological function the enzyme converts chondroitin sulfate (CS) to a CS/dermatan sulfate (DS) hybrid chain, which is structurally and conformationally richer than CS, favouring interaction with matrix proteins and growth factors. Xenopus Dse is essential for the migration of neural crest cells by allowing cell surface CS/DS proteoglycans to adhere to fibronectin Xenopus laevis