KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.067 | - |
D-glucuronosyl residues | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | most of the L-iduronic acid residues generated by the enzyme occur singly, although some formation of two or three consecutive L-iduronic acid residue containing disaccharide units is observed | ? | - |
? | |
additional information | Homo sapiens | epimerization of D-glucuronosyl residues to L-iduronosyl during biosynthesis of dermatan sulfate | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
Chondroitin D-glucuronate = dermatan L-iduronate | two-base reaction mechanism, involving a monoprotic L-iso-specific base and a polyprotic D-gluco-specific base | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | skin | Homo sapiens | - |
fibroblast | embryonic | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Chondroitin D-glucuronate | capsular polysaccharide from Escherichia coli K4 consists of a chondroitin backbone to which beta-fructofuranose units are linked to C-3 of the D-glucuronic acid residues. Removal of the fructose units by mild acid hydrolysis provides a substrate for the chondroitin-glucuronate 5-epimerase | Homo sapiens | Dermatan L-iduronate | - |
? | |
D-glucuronosyl residues | - |
Homo sapiens | L-iduronosyl residues | - |
? | |
additional information | most of the L-iduronic acid residues generated by the enzyme occur singly, although some formation of two or three consecutive L-iduronic acid residue containing disaccharide units is observed | Homo sapiens | ? | - |
? | |
additional information | epimerization of D-glucuronosyl residues to L-iduronosyl during biosynthesis of dermatan sulfate | Homo sapiens | ? | - |
? |