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Literature summary for 5.1.3.14 extracted from

  • Penner, J.; Mantey, L.R.; Elgavish, S.; Ghaderi, D.; Cirak, S.; Berger, M.; Krause, S.; Lucka, L.; Voit, T.; Mitrani-Rosenbaum, S.; Hinderlich, S.
    Influence of UDP-GlcNAc 2-epimerase/ManNAc kinase mutant proteins on hereditary inclusion body myopathy (2006), Biochemistry, 45, 2968-2977.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Insect Cells and supercompetent InvalphaF' Escherichia coli cells (Invitrogen) Escherichia coli

Protein Variants

Protein Variants Comment Organism
C303V exhibited almost no reduction in epimerase activity Escherichia coli
C303X the C303X protein does not display any enzymatic activity Escherichia coli
D378Y 60% reduction of epimerase activity Escherichia coli
I200F exhibited almost no reduction in epimerase activity Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-GlcNAc Escherichia coli biosynthetic pathway of sialic acid ManNAc + UDP
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli P27828
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-GlcNAc biosynthetic pathway of sialic acid Escherichia coli ManNAc + UDP
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Escherichia coli

Synonyms

Synonyms Comment Organism
UDP-GlcNAc 2-epimerase
-
 Escherichia coli
UDP-N-acetylglucosamine 2-epimerase
-
 Escherichia coli