Cloned (Comment) | Organism |
---|---|
- |
Mycobacterium tuberculosis |
Protein Variants | Comment | Organism |
---|---|---|
C185S | decrease in racemization activity, mutant retains its gyrase inhibition ability | Mycobacterium tuberculosis |
C75S | decrease in racemization activity, mutant retains its gyrase inhibition ability | Mycobacterium tuberculosis |
C75SC185S | less than 10% of wild-type activity, mutant retains its gyrase inhibition ability | Mycobacterium tuberculosis |
additional information | overexpression in vivo provides resistance to the action of ciprofloxacin | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mycobacterium tuberculosis | enzyme exhibits both racemization activity and DNA gyrase inhibition. The two activities are unlinked and independent of each other. Enzyme-DNA gyrase interaction influences gyrase activity but has no effect on the racemization activity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme exhibits both racemization activity and DNA gyrase inhibition. The two activities are unlinked and independent of each other. Enzyme-DNA gyrase interaction influences gyrase activity but has no effect on the racemization activity | Mycobacterium tuberculosis | ? | - |
? |