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Literature summary for 5.1.1.18 extracted from

  • Mustafa, A.K.; van Rossum, D.B.; Patterson, R.L.; Maag, D.; Ehmsen, J.T.; Gazi, S.K.; Chakraborty, A.; Barrow, R.K.; Amzel, L.M.; Snyder, S.H.
    Glutamatergic regulation of serine racemase via reversal of PIP2 inhibition (2009), Proc. Natl. Acad. Sci. USA, 106, 2921-2926.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.1.1.18

Activating Compound

Activating Compound Comment Organism Structure
ATP competes with inhibitor phosphatidylinositol(4,5)-bisphosphate for enzyme binding Mus musculus
metabotropic glutamate receptor i.e. mGluR5, on glia, activation mechanism of the D-serine synthesis needed for NMDA neurotransmission, overview Mus musculus
additional information the glutamate transmission activates the enzyme by degrading phospholipids Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
HEK293 cells transfected with wild-type enzyme and metabotropic glutamate receptor display a 4fold increase in enzyme activity upon treatment with the metabotropic glutamate receptor agonist dihydroxyphenylglycine Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information enzyme mutants that cannot bind phosphatidylinositol(4,5)-bisphosphate lose their membrane localizations and display a 4fold enhancement of catalytic activity. Moreover, metabotropic glutamate receptors activation of the enzyme activity is abolished by inhibiting phospholipase C Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
phosphatidylinositol-4,5-bisphosphate i.e. PIP2, a physiological inhibitor of the enzyme, competes with activator ATP for enzyme binding. Activation of metabotropic glutamate receptors on glia leads to phospholipase C-mediated degradation of PIP2, relieving SR inhibition Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane membrane association via phospholipid binding. The enzyme is prominently associated with the plasma membrane but also is detected in granular structures that may be vesicles associated with the plasma membrane or other cellular components Mus musculus 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-serine Mus musculus D-serine is stored primarily within astrocytes ensheathing neuronal synapses containing NMDA receptors, model of D-serine signalling in the brain, overview D-serine
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
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 Mus musculus
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brain
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 Mus musculus
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glia
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 Mus musculus
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neuron
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine
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 Mus musculus D-serine
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 ?
L-serine D-serine is stored primarily within astrocytes ensheathing neuronal synapses containing NMDA receptors, model of D-serine signalling in the brain, overview Mus musculus D-serine
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 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.013
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-
 Mus musculus phosphatidylinositol-4,5-bisphosphate