Application | Comment | Organism |
---|---|---|
drug development | serine racemase inhibitors might be useful in treatment of neurodegenrative diseases | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of enzyme mutants by random mutagenesis for determination of structurally and functionally important residues in the enzyme, e.g. S84 and P111, that are crucial for enzyme activity, and C217 and K221 that are important for Mg2+ binding and enzyme stability | Homo sapiens |
General Stability | Organism |
---|---|
enzyme residues C217 and K221 are important for Mg2+ binding and enzyme stability | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | enzyme residues C217 and K221 are important for Mg2+ binding and enzyme stability | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-serine | Homo sapiens | - |
D-serine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-serine | - |
Homo sapiens | D-serine | - |
? | |
L-serine | enzyme residues S84 and P111 are crucial for enzyme activity | Homo sapiens | D-serine | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | dependent on | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | increased levels of enzyme-mediated D-serine production are associated with amyotrophic lateral sclerosis and Alzheimer's disease | Homo sapiens |
physiological function | the enzyme is responsible for D-serine production in the central nervous system, where D-serine acts as a co-agonist of the N-methyl-D-aspartate receptor ion channels | Homo sapiens |