Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.1.1.18 extracted from

  • Steffek, A.E.; Haroutunian, V.; Meador-Woodruff, J.H.
    Serine racemase protein expression in cortex and hippocampus in schizophrenia (2006), NeuroReport, 17, 1181-1185.
    View publication on PubMed
Search for more literature for 5.1.1.18

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-serine Homo sapiens the astrocytic enzyme synthesizes the N-methyl-D-aspartate receptor coagonist D-serine, and is involved in development of schizophrenia and glutamatergic dysfunction, astrocytes may play a direct role in N-methyl-D-aspartate receptor dysfunction in schizophrenia, overview D-serine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
 Homo sapiens
-
brain post-mortem sample, increased expression in cortex and hippocampus in schizophrenia Homo sapiens
-
brain cortex increased expression in schizophrenia Homo sapiens
-
hippocampus increased expression in schizophrenia Homo sapiens
-
neuron
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine
-
 Homo sapiens D-serine
-
 ?
L-serine the astrocytic enzyme synthesizes the N-methyl-D-aspartate receptor coagonist D-serine, and is involved in development of schizophrenia and glutamatergic dysfunction, astrocytes may play a direct role in N-methyl-D-aspartate receptor dysfunction in schizophrenia, overview Homo sapiens D-serine
-
 ?