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Literature summary for 5.1.1.18 extracted from
- D-Amino acid oxidase and serine racemase in human brain: normal distribution and altered expression in schizophrenia (2007), Eur. J. Neurosci., 26, 1657-1669.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-serine | Homo sapiens | D-serine is an N-methyl-d-aspartate receptor co-agonist, synthesized by serine racemase and degraded by d-amino acid oxidase | D-serine | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | cerebellum and dorsolateral prefrontal cortex, the enzyme is principally glial in all regions, but shows altered expression in schizophrenia increasing in the dorsolateral prefrontal cortex but not in cerebellum, expression analysis in healthy and schizophrenic brains, overview, no expression in Substantia nigra or in dentate gyrus granule cells or pyramidal neurons of the hippocampus and the dorsolateral prefrontal cortex, no expression in granule cells and Golgi cells of he cerebellum | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-serine | - |
Homo sapiens | D-serine | - |
? | |
| L-serine | D-serine is an N-methyl-d-aspartate receptor co-agonist, synthesized by serine racemase and degraded by d-amino acid oxidase | Homo sapiens | D-serine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SRR | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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