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Literature summary for 5.1.1.18 extracted from

  • Wu, S.; Basile, A.S.; Barger, S.W.
    Induction of serine racemase expression and D-serine release from microglia by secreted amyloid precursor protein (sAPP) (2007), Curr. Alzheimer Res., 4, 243-251.
    View publication on PubMed
Search for more literature for 5.1.1.18

Activating Compound

Activating Compound Comment Organism Structure
additional information the amyloid beta-peptide and secreted forms, liberated by alpha- or beta-secretase, of beta-amyloid precursor protein induce enzyme expression and lead to elevated D-serine levels in microglia, overview Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
cloning from genomic DNA, DNA and amino acid sequence determination Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-serine Rattus norvegicus
-
 D-serine
-
 ?
L-serine Homo sapiens
-
 D-serine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9GZT4
-
-
Rattus norvegicus
-
 Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocytoma cell
-
 Homo sapiens
-
HAP1 cell a microglial cell line Rattus norvegicus
-
microglia primary from neonatal rats, mixed glial cultures Rattus norvegicus
-
T-98G cell an astrocytoma cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine
-
 Rattus norvegicus D-serine
-
 ?
L-serine
-
 Homo sapiens D-serine
-
 ?

Synonyms

Synonyms Comment Organism
SRace
-
 Rattus norvegicus
SRace
-
 Homo sapiens