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Literature summary for 5.1.1.18 extracted from
- Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine (2002), Proc. Natl. Acad. Sci. USA, 99, 14542-14547.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ADP | less effective than ATP | Mus musculus |  |
| ATP | and MG2+, up to 5fold stimulation | Mus musculus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | strong | Mus musculus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | and ATP, up to 5fold stimulation | Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
bifunctional enzymes, racemization of serine and elimination of L-serine to form pyruvate | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-serine | - |
Mus musculus | pyruvate + NH3 | - |
? | |
| L-serine | - |
Mus musculus | D-serine | - |
r | |
| additional information | ratio of synthesized pyruvate/D-serine is about 3 | Mus musculus | ? | - |
? | |
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Release 2023.1 (January 2023)
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