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Literature summary for 5.1.1.18 extracted from

  • Strisovsky, K.; Jiraskova, J.; Barinka, C.; Majer, P.; Rojas, C.; Slusher, B.S.; Konvalinka, J.
    Mouse brain serine racemase catalyzes specific elimination of L-serine to pyruvate (2003), FEBS Lett., 535, 44-48.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Co2+
-
Mus musculus
Cu2+
-
Mus musculus
EDTA
-
Mus musculus
Fe2+ slight inhibition of both activities Mus musculus
Ni2+ slight inhibition of both activities Mus musculus
Zn2+
-
Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
30
-
L-serine pH 8.0, 37°C, racemization reaction Mus musculus
49
-
D-serine pH 8.0, 37°C, racemization reaction Mus musculus
75
-
L-serine pH 8.0, 37°C, elimination reaction Mus musculus
75
-
D-serine pH 8.0, 37°C, elimination reaction Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
Mus musculus
Mg2+ required, both activities Mus musculus
Mn2+
-
Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37000
-
2 * 37000, SDS-PAGE Mus musculus
78000
-
gel filtration Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q9QZX7 bifunctional enzyme, racemization of serine and elimination of L-serine and L-serine-O-sulfate to form pyruvate
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme expressed in insect cells Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-serine
-
Mus musculus pyruvate + NH3
-
?
D-serine
-
Mus musculus L-serine
-
r
L-serine
-
Mus musculus pyruvate + NH3
-
?
L-serine
-
Mus musculus D-serine
-
r

Subunits

Subunits Comment Organism
dimer 2 * 37000, SDS-PAGE Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8 9.5
-
Mus musculus

pH Range

pH Minimum pH Maximum Comment Organism
6.5
-
negligible activity below Mus musculus