Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Dihydroxyfumarate | - |
Mus musculus | |
glycine | competitive | Mus musculus | |
L-asparagine | - |
Mus musculus | |
L-cysteine-S-sulfate | - |
Mus musculus | |
L-erythro-3-hydroxyaspartate | - |
Mus musculus | |
Maleate | - |
Mus musculus | |
malonate | - |
Mus musculus | |
meso-tartrate | - |
Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.49 | - |
L-serine O-sulfate | pH 8.0, 37°C, presence of 1 mM ATP, elimination reaction | Mus musculus | |
3.2 | - |
D-serine | pH 8.0, 37°C, presence of 1 mM ATP, elimination reaction | Mus musculus | |
3.8 | - |
L-serine | pH 8.0, 37°C, presence of 1 mM ATP, racemization reaction | Mus musculus | |
4 | - |
L-serine | pH 8.0, 37°C, presence of 1 mM ATP, elimination reaction | Mus musculus | |
14.5 | - |
D-serine | pH 8.0, 37°C, presence of 1 mM ATP, racemization reaction | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
36121 | - |
x * 36121, MALDI-MS, x * 36123, calculated | Mus musculus |
36123 | - |
x * 36121, MALDI-MS, x * 36123, calculated | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9QZX7 | bifunctional enzyme, racemization of serine and elimination of L-serine and L-serine-O-sulfate to form pyruvate | - |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-serine | - |
Mus musculus | pyruvate + NH3 | - |
? | |
D-serine | - |
Mus musculus | L-serine | - |
r | |
L-serine | - |
Mus musculus | pyruvate + NH3 | - |
? | |
L-serine | - |
Mus musculus | D-serine | - |
r | |
L-serine O-sulfate | - |
Mus musculus | O-sulfopyruvate + NH3 | - |
? | |
additional information | racemization and elimination activities reside at the same active site of enzyme. Racemization activity is specific to serine, elimination activity has a broader specificity for L-amino acids with a suitable leaving group at the beta-carbon | Mus musculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 36121, MALDI-MS, x * 36123, calculated | Mus musculus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.49 | - |
L-serine O-sulfate | pH 8.0, 37°C, presence of 1 mM ATP, elimination reaction | Mus musculus | |
3.2 | - |
D-serine | pH 8.0, 37°C, presence of 1 mM ATP, elimination reaction | Mus musculus | |
3.8 | - |
L-serine | pH 8.0, 37°C, presence of 1 mM ATP, racemization reaction | Mus musculus | |
4 | - |
L-serine | pH 8.0, 37°C, presence of 1 mM ATP, elimination reaction | Mus musculus | |
14.5 | - |
D-serine | pH 8.0, 37°C, presence of 1 mM ATP, racemization reaction | Mus musculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.043 | - |
L-erythro-3-hydroxyaspartate | pH 8.0, 37°C | Mus musculus | |
0.071 | - |
malonate | pH 8.0, 37°C | Mus musculus | |
0.55 | - |
Maleate | pH 8.0, 37°C | Mus musculus | |
0.64 | - |
L-cysteine-S-sulfate | pH 8.0, 37°C | Mus musculus | |
0.66 | - |
meso-tartrate | pH 8.0, 37°C | Mus musculus | |
0.69 | - |
Dihydroxyfumarate | pH 8.0, 37°C | Mus musculus | |
1.13 | - |
L-asparagine | pH 8.0, 37°C | Mus musculus | |
1.64 | - |
glycine | pH 8.0, 37°C | Mus musculus |