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Literature summary for 5.1.1.1 extracted from

  • Faraci, W.S.; Walsh, C.T.
    Racemization of alanine by the alanine racemase from Salmonella typhimurium and Bacillus stearothermophilus: energetic reaction profiles (1988), Biochemistry, 27, 3267-3276.
    View publication on PubMed
Search for more literature for 5.1.1.1

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.5
-
 D-Ala alr gene encoded Salmonella enterica subsp. enterica serovar Typhimurium
1.7
-
 L-Ala alr gene encoded Salmonella enterica subsp. enterica serovar Typhimurium
2.2
-
 D-Ala D-Ala, dadB encoded enzyme Salmonella enterica subsp. enterica serovar Typhimurium
2.7
-
 L-Ala
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7
-
 L-Ala D-Ala Geobacillus stearothermophilus
4.4
-
 L-Ala
-
 Geobacillus stearothermophilus
11
-
 L-Ala dadB gene encoded Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-Ala Salmonella enterica subsp. enterica serovar Typhimurium enzyme provides D-Ala as an essential building block for biosynthesis of the peptidoglycan layer of the cell wall ?
-
 ?
L-Ala Geobacillus stearothermophilus enzyme provides D-Ala as an essential building block for biosynthesis of the peptidoglycan layer of the cell wall ?
-
 ?

Organism

Organism UniProt Comment Textmining
Geobacillus stearothermophilus
-
-
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
 encoded by the dadB and alr gene
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ala
-
 Salmonella enterica subsp. enterica serovar Typhimurium D-Ala
-
 ?
L-Ala
-
 Geobacillus stearothermophilus D-Ala
-
 ?
L-Ala enzyme provides D-Ala as an essential building block for biosynthesis of the peptidoglycan layer of the cell wall Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
L-Ala enzyme provides D-Ala as an essential building block for biosynthesis of the peptidoglycan layer of the cell wall Geobacillus stearothermophilus ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1
-
 L-Ala
-
 Geobacillus stearothermophilus
1.6
-
 D-Ala dadB encoded enzyme Salmonella enterica subsp. enterica serovar Typhimurium
2.6
-
 D-Ala alr encoded enzyme Salmonella enterica subsp. enterica serovar Typhimurium
7
-
 D-Ala
-
 Geobacillus stearothermophilus
7.3
-
 L-Ala dadB encoded enzyme Salmonella enterica subsp. enterica serovar Typhimurium
9.7
-
 L-Ala alr encoded enzyme Salmonella enterica subsp. enterica serovar Typhimurium

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate pyridoxal 5'-phosphate dependent enzyme Salmonella enterica subsp. enterica serovar Typhimurium
pyridoxal 5'-phosphate pyridoxal 5'-phosphate dependent enzyme Geobacillus stearothermophilus