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Literature summary for 4.6.1.23 extracted from

  • Larsson, S.L.; Sloma, M.S.; Nygard, O.
    Conformational changes in the structure of domains II and V of 28S rRNA in ribosomes treated with the translational inhibitors ricin or alpha-sarcin (2002), Biochim. Biophys. Acta, 1577, 53-62.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
rRNA + H2O Aspergillus giganteus
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?
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?

Organism

Organism UniProt Comment Textmining
Aspergillus giganteus
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filamentous fungus, mold
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information alpha-sarcin modifies neighbouring sites in the sarcin/ricin loop of 28S rRNA, destroying the necessary dynamic flexibility of the ribosome, inhibiting the elongation factor assisted steps of the elongation cycle Aspergillus giganteus ?
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rRNA + H2O
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Aspergillus giganteus ?
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?